Ethano-anthracenes



United States Patent O US. Cl. 260-562 6 Claims ABSTRACT OF THE DISCLOSURE 9 acylamino-lower alkyl 9:10-dihydro-9:10-ethano- (122)-anthracenes are valuable intermediates for the preparation of 9 R alk 9:l0-dihydro-9;l0-ethano- 1:2)-anthracenes, wherein alk is a lower alkylene radical and R is an amino group carrying at least one substituted or unsubstituted methyl group, as Well as of their quaternary ammonium compounds and salts, which compounds, especially the amines and the therapeutically acceptable salts thereof, display an inhibitory action on the central nervous system characterized by an antagonism towards psychomotoric substances such, for example, as mescalin, and inhibit the transmission of spinal reflexes and can therefore be used as tranquilizers.

CROSS-REFERENCES This is a continuation-in-part application of our pending application Ser. No. 541,979, filed Apr. 12, 1966 which is a continuation-in-part of our application Ser. No. 404,904, filed Oct. 19, 1964, which in turn is a continuation-in-part of our application Ser. No. 151,198, filed Nov. 9, 1961, and of our application Ser. No. 512,201, filed Dec. 7, 1965.

SUMMARY OF THE INVENTION The present invention concerns and has for its object the provision of new 9-acylamino-lower alkyl-9:10-dihydro-9:IO-ethano-(l:2)anthracenes which are valuable intermediates for the preparation of 9-Ralk-9:l0-dihydro- 9: IO-ethano-(l :2)-anthracenes, wherein alk is a lower alkylene radical and R is an amino group carrying at least one substituted or unsubstituted methyl group, as well as of their q'uarternary ammonium compounds and salts, which compounds, especially the amines and the therapeutically acceptable salts thereof, display an inhibitory action on the central nervous system characterized by an antagonism towards psychomotoric substances such, for example, as mescalin, and inhibit the transmission of spinal reflexes and can therefore .be used as tranquilizers.

'Ihe acylamino-lower alkyl-compounds are converted into the final products by reduction.

DESCRIPTION OF THE PREFERRED EMBODIMENTS In the new final compounds the amino group is monoor disubstituted. Particularly suitable substituents are the following with the proviso that the amino group must carry at least one methyl or methylene group which is formed by the reduction of the acyl substituent. As subsuch as fluorine, chlorine, bromine or iodine. As lower 3,489,799 Patented Jan. 13, 1970 hydrocarbon residues there may be mentioned above all:

Lower alkyl or alkenyl groups such as methyl, ethyl, propyl, or isopropyl; straight or branched butyl, pentyl, hexyl, or heptyl radicals bound in any desired position; allyl or methallyl radicals unsubstituted or alkyl-substituted cycloalkyl or cyclo-alkenyl groups such as cyclopentyl, cyclohexyl, cycloheptyl, cyclopentyl, cyclohexenyl groups; unsubstituted or alkyl-substituted cycloalkylalkyl or cycloalkenyl-alkyl groups such as cyclopentylor cyclohexenyl-methyl, -ethyl or -propyl groups; aralkyl or aralkenyl such as phenyl-methyl, -ethyl, vinyl or propyl groups; or aryl, more especially phenyl radicals; or alkylene or alkenylene groups such, for example as 'butylene- (1:4), pentylene(l:5), 1:S-dimethylpentylene-(l:5), hexylene-(1z6) and hexylene-(l :5). Residues of this kind interrupted by hetero atoms are, for example, alkoxyalkyl or oxa-cycloalkyl-alkyl groups such as methoxyethyl, ethoxyethyl propoxyethyl, butoxyethyl, methoxypropyl, methoxyethoxyethyl, tetrahydrofurylmethyl, methyl-mercaptoethyl, oxa-, azaor thia-alkylene or -alkenylene residues such as 3-aza-, oxaor thia-pentylene-(lzS), 3-azahexylene (1:6),, 1:5 dimethyl 3-aza pentylene-(lzS), 3 methyl 3 aza-pentylene-(lzS), or 3-hydroxyethyl- 3-aza-pentylene-(1:5). The amino group is above all a monoof di-lower alkyl-amino group such as the methylamino, ethylamino, n-butylamino, dimethylamino, diethylamino, dipropylamino, N methyl N ethylamino group, or an N-lower alkyl-N-cyclo-alkylamino group such as the N-methyl-N-cyclopentyl or -cyclohexyl group; or a pyrrolidino, piperidino, morpholino or thia-morpholino group such as the pyrrolidino, piperidino, morpholino, piperazino, N-methyl-, N-ethylor N-fi-hydroxyethylpiperazino group.

The fourth substituent on a quaternary ammonium group is above all a lower alkyl or alkenyl group such as a methyl, ethyl, allyl, propyl, of benzyl group or a phenoxy-lower alkyl such as the phenoxyethyl group.

The alkylene residue which connects the aforementioned amino group with the anthracene nucleus is above all a lower unbranched or branched alkylene group which preferably contains 1 to 4 carbon atoms such, for example as a methylene, ethylene-(1:2), propylene-(1:2), propylene-(1:3), butylene-(1z2), butylene-(1z3), butylene- (2:3) or butylene-(1:4) residue.

The new compounds can be further substituted, for example, in positions 1 to 8 of the anthracene ring or on other aromatic rings by lower alkyl, alkoxy, alkenyloxy or alkylmercapto groups, by halogen atoms such as fluorine, chlorine, bromine or iodine or by the pseudohalogen trifluoromethyl, by alkylsulphonyl, alkanoyl, nitro or amino groups, and in this connection there may be mentioned as alkyl groups, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, or tertiary butyl; as alkoxy or alkenyloxy groups the methoxy, ethoxy, allyloxy or methylenedioxy group; as alkylmercapto the methyl mercapto or ethylmercapto' group; and as alkanoyl groups above all the acetyl, propionyl or butyryl residue. position 10 the new compounds may contain above all an aliphatic hydrocarbon residue such as one of the abovementioned lower alkyl or alkenyl groups, or a halogen atom.

The new compounds have valuable pharmacological properties; inter alia they display an inhibitory action on the central nervous system characterized by an antagonism towards psychomotoric substances such, for example, as mescalin, and inhibit the transmission of spinal reflexes; and they can therefore be used as tranquilizers in human and veterinary medicine. They are also suitable as additives to animal fodder, since they bring about a better intake. 7 M

In addition, the new compounds may be used as starting material or intermediates for the preparation of other valuable compounds.

Of special value are the 9-aminomethyland 9-aminopropyl 9:10 dihydro 9:10 ethano-(1:2)-anthracenes and their salts and amongst them especially those in which the amino group is secondary or tertiary, preferably being a monoor di-lower alkyl amino or cycloalkylamino, pyrrolidino, piperidino, morpholino, piperazino, N- methylpiperazino, N ethylpiperazino or N-fihydroxyethylpiperazino group.

Special mention deserve the compounds of the formula CH A CH and and their salts, in which A represents a secondary or tertiary amino group, more especially one of the lastmentioned amino groups, especially a dimethylaminoor methylamino group. Of primary importance are 9-methylamino-methyl-, 9-n-butylamino-methyl-, 9-dimethylaminomethylor 9 diethylamino methyl 9:10 dihydro- 9:10 ethano (1:2) anthracene, 9 'y dimethylaminopropyl 9:10 dihydro 9:10 ethano -(1:2) anthracene, 9 'y methylamino propyl 9: 10 dihydro 9: 10- ethano (1:2 anthracene and 9 ['y (N hydroxyethyl-piperazino) propyl] 9: 10 dihydro 9: IO-ethano- (1,2)-anthracene and their salts.

The new compounds are prepared by as such known methods.

Thus, for example, a residue convertible into an aminoalkyl or ammonium-alkyl group, present in position 9 of a 9:10-dihydro-9:l0-alkano-(1:2) anthracene may be so converted. A residue convertible into an aminoalkyl or ammoniumalkyl group is for example one which is convertible into an aminoalkyl group by reduction, for example carbamyl, or carbamylalkyl groups which can be reduced in conventional manner, advantageously with lithium-aluminum hydride or a similar reducing agent for amides, to form the corresponding aminoalkyl groups.

Similarly, nitroalkyl, nitroalkenyl, cyano or cyanoalkyl groups can be reduced to the corresponding aminoalkyl groups, the reduction of said groupings being carried out with the use of a conventional agent such, for example as activated hydrogen, more especially catalytically activated hydrogen. Catalysts particularly suitable for this purpose are Rupe or Raney nickel, or platinum or palladium catalysts.

Further groups that can be reduced to amino-alkyl groups are iminoalkyl residues or the corresponding amino-hydroxy-alkyl residues which can be converted into the aminoalkyl residues with the use of a conventional reducing agent, primarily a metal hydride, for example a di-light metal hydride, such as alkali metal borohydride, or catalytically activated hydrogen, for which purpose platinum oxide and Raney nickel are especially suitable catalysts. As iminoalkyl residues there are suitable, apart from the usual Schifis bases, also hydroxyimino-alkyl groups.

According to another process the 9:lDethano-(l:2)

residue is introduced in conventional manner into a 9- aminoalkyl-anthracene,'or into a quaternary ammonium derivative or a salt thereof, advantageously with the use of ethylene, by the Diels-Alder method; depending on the reactivity of the anthracene compound this reaction may have to be carried out at an elevated temperature and/or under superatmospheric pressure and/or in the presence of a catalyst;

In a resulting primary, secondary or tertiary amino group further nitrogen substitutents may he introduced in known manner, for example by treatment with a reactive ester, for example one of those mentioned above, Q wit a crrssp s Q 'PQQQl; at by edu ive a y ation with the use of an appropriate carbonyl compound or by acylation with carboxylic acids or their functional derivatives and reduction of the obtained N-acyl compounds.

Furthermore, substituents may be introduced into the benzene nuclei, such as niiro groups, which may be effected by nitration. substituents present in the molecule can be converted in the conventional manner, for example nitro groups on the aromatic residues may be reduced to amino groups.

' The invention further includes any variant of the present process in which an intermediate obtained at any stage of the process is used as starting material and/or the remaining step or steps is/are carried out; or the process is discontinued at any stage thereof; or in which a starting material is formed in the course of the reaction, or used in the form of a quaternary ammonium compound or a salt thereof. Thus, for example, the starting material may be a 9-oxoalkyl-9:l0-dihydro-9:10-ethano- (1:2)-anthracene, for example a 9-formyl or 9-formylalkyl compound, which is treated under suitable reducing conditions, for example those mentioned above for reducing iminoalkyl groups, with ammonia or with a primary or secondary amine, which procedure yields as intermediate one of the aforementioned iminohydroxy or aminohydroxy compounds.

The aforementioned reactions are carried out in the usual manner in the presence or absence of diluents, condensing agents and/or catalysts, at room temperature or a lower or higher temperature, if desired under superatmospheric pressure.

The starting materials are known or can be prepared by known methods. Any new starting materials used are likewise included in the invention.

Depending on the reaction conditions and starting material used the new compounds are obtained in the free form or in the form of salts thereof. The salts of the new compounds can be converted in known manner into the free compounds, for example acid addition salts by reaction with a basic agent. On the other hand, a resulting free base may form salts with inorganic or organic acids. Acid addition salts are preferably manufactured with therapeutically useful acids, for example a hydrohalic acid such as hydrochloric or hydrobromic acid, perchloric, nitric or thiocyanic acid, a sulphuric or phosphoric acid, or an organic acid such as formic, acetic, propionic, glycollic, lactic, pyruvic, oxalic, malonic, succinic, maleic, fumaric, malic, tartaric, citric, ascorbic, hydroxymaleic, dihydroxymaleic, benzoic, phenylacetic, 4 amino-benzoic, 4 hydroxybenzoic, anthranilic, cinnamic, mandelic, salicylic, 4 aminosalicylic, 2 phenoxybenzoic, 2 acetoxybenzoic, methanesulphonic, ethanesulphonic, hydroxyethanesulphonic, benzenesulphonic, paratoluene-sulphonic, naphthalenesulphonic, or sulphanilic acid; methionine, tryptophan, lysine or arginine. The salts may be monosalts or polysalts.

Quaternary ammonium salts may also be converted into the ammonium hydroxides, for example by treatment of an ammonium halide with freshly precipitated silver oxide, or by treating an ammonium sulphate with barium hydroxide solution, or with the use of a basic ion-exchanger, and from the resulting ammonium hydroxide other ammonium salts can be prepared by reaction with an acid, for example one of those mentioned above. If desired, this exchange may also be carried out directly with the use of suitable ion-exchanger.

The new compounds are intended to be used as medicaments in the form of pharmaceutical preparations conterol or other known medicinal 'excipients. The pharmaceutical preparations may be, for example, tablets, dragees or capsules, or in liquid for solutions, suspensions or emulsions. Theymay be sterilised and/or may contain assistants such as preserving, stabilising, wetting or emulsifying agents, salts for regulating the osmotic pressure or buffers. The dosage of the new compounds may vary according to the particular compound and the particular needs of the patient. Usually it is in the range of 25-500 mg. daily, for example between 75 and 300 mg.; the dose may be divided and thus administered twice or three times a day. They may also contain other therapeutically valuable substances. I

The new compounds may also be used in veterinary medicine, for example in one of the forms mentioned above, or in the raising and feeding of animals in the form of fodders or as additives to animal fodder, for example in admixture with the conventional extenders and diluents and feeding stufls respectively.

The following examples illustrate the invention.

Example 1 A solution of 9.0 grams of 9:10 dihydro 9:10 ethano (1:2) anthracene (9) carboxylic acid diethylamide in 50 cc. of tetrahydrofuran is stirred dropwise at room temperature into a suspension of 2.5 grams of lithium-aluminium hydride in 100 cc. of tetrahydrofuran. The mixture is heated for 3 hours at the boil and then cooled in ice. The organo-metal complexes and the excess of lithium-aluminium hydride are decomposed by carefully dropping in 2.5 cc. of water, 2.5 cc. of sodium hydroxide solution of 15% strength and 7.5 cc. of water. The granular precipitate formed is filtered off and the solvent is evaporated, to yield 9 diethylamino methyl- 9:10 dihydro 9:10 ethano (1:2) anthracene of the formula which melts at 112 to 115 C. after having been recrystallised from ethanol. Its hydrochloride melts at 243 to 245 C.

The 9:10 dihydro 9:10 ethano (1:2) anthracene (9) carboxylic acid diethylamide used as starting material is prepared in the following manner:

A mixture of 10.0 grams of 9:10 dihydro 9:10 ethano (1:2) anthracene (9) carboxylic acid and 100 cc. of thionyl chloride is refluxed for 6 hours; the thionyl chloride is then evaporated to leave an oil which crystallises when left to itself for some time. Recrystallisation from petroleum ether yields the 9:10 dihydro 9: 10 ethano (1:2) anthracene (9) carboxylic acid chloride of the formula in crystals melting at 72 to 75. C.

10.0 grams of diethylaminein 25 cc. of benzene are vigorously stirred dropwise at room temperature into 5 grams of the acid chloride in 50 cc. of benzene. The mixture is stirred for 2 hours at 40 C. and then extracted with water. On evaporation of the benzene an oil remains which crystallises slowly. Recrystallisation from aqueous 6 methanol yields the 9: 10-dihydro-9:l0-ethano-(1:2)-an thracene-(9)-carboxylic acid diethylamide of the formula in crystals melting at 108 to 109 C.

Example 2 ca -na-ca -ca Q acl which melts at 253 to 255 C, after having been recrystallised from ethanol-i-ether.

The 9:10-dihydro-9:10-ethano-(1:2)-anthracene (9)- aldehyde used as starting material is prepared as follows:

A solution of 50 grams of anthracene-(9)-aldehyde in 200 cc. of dimethylformamide is heated in an autoclave with ethylene to 170 C., the whole is cooled after 24 hours, and the solvent is evaporated in a water-jet vacuum. The residue is dissolved in a small amount of chloroform. On addition of ethanol the 9:10-dihydro-9z10-ethano- (1:2)-anthracene-(9)-aldehyde of the formula crystallises in the form of prisms melting at 106 to 107 C.

Example 3 ,is no longer being consumed, the catalyst is filtered off and the solvent evaporated, to'yield 9-(n-butyl-aminomethyl)-9:10-dihydro-9:10-ethano-(1z2) anthracene of the formula which melts at 76 to 78 C. after having been recrystallised from ethanol.

7 Example 4 A solution of 10 grams of 9:10-dihydro-9:l0-ethano- (1:2)-anthracene-(9)-aldehyde and 10 grams of monomethylamine in 100 cc. of ethanol is heated at 80 C. for 4 hours in an autoclave. The reaction mixture is then evaporated to dryness under reduced pressure to leave a crystalline residue which is dissolved in 150 cc. of ethanol and, after the addition of 2 grams of Raney nickel, hydrogenated at 40 C. under atmospheric pressure. When the absorption of hydrogen has subsided, the catalyst is filtered oif and the filtrate evaporated under reduced pressure. An oil remains which is covered with 100 cc. of 2 N-hydrochloric acid. The 9-methylamino-methyl-9:lO-dihydro- 9:l0-ethano-(1:2)-anthracene hydrochloride of the formula CH dill-CH crystallizes immediately; after crystallization from methanol it melts at 320-322 C.

Example 5 which melts at 78-80 C. after crystallization from ethanol; its hydrochloride melts at 233-234 C. In an analogous manner from 9-(n-butylamino-methyl)-9:lO-dihydro-9: IO-ethano-(l:2)-anthracene there is obtained 9-(N- methyl-N-n-butylamino methyl) 9: 10 dihydro 9:10- ethano-(1:2)-anthracene melting at 257 C. hydrochloride.

Example 6 A solution of 17.8 grams of N-acetyI-Q-methylaminomethyl 9:10 dihydro 9:10 ethano-(l:2)-anthracene in 50 cc. of tetrahydrofuran is added dropwise with stirring, to 4 grams of lithium-aluminium hydride in 100 cc. of tetrahydrofuran. The mixture is then stirred for 2 hours at 50 C. 4 cc. of Water, 4 cc. of sodium hydroxide solution of strength and 12 cc. of water are then added to the reaction mixture, the precipitateformed is filtered with suction and the filtrateevaporated to drynessunder reduced pressure to yield 9- (methyl-ethylamino-methyl)- 9:10 dihydro 9:10 ethano (1:2) anthracene of the formula I which melts at 7779 C. after crystallization from methanol; its hydro hloride melts at 235-236 C.

8 'The N-acetyl-9-methylamino-methyl 9:10 dihydro- 9:10-ethano-( l:2)-anthracene used asstarting material may be prepared in the conventional manner by acetylating 9-methylamino '9:10'- dihydro 9:10 ethano- (l:2)-anthracene with acetyl chloride in pyridine. The compound melts at 128 C. after recrystallization from ethanol. Y

Example 7.

10 grams of 9 -.cyano 9:10 dihydro 9:10-ethano- (1:2)-anthracene are dissolved in 200 cc. of ethanol. The solution is saturated with ammonia and after the addition of 2 grams of Raney nickel hydrogenated at C. under 70 atmospheres gauge pressure. When the absorption of hydrogen has subsided, the catalyst is filtered otf and the filtrate evaporated to dryness under reduced pressure. The residue is treated with 2 N-hydrochloric acid, the hydrochloride of 9-aminomethyl-9z10- dihydro-9:10-ethano-(1:2)-anthracene of the formula precipitating in the form of crystals melting at 313- 315 C.

Example 8 cu -M0119 which is converted into its hydrochloride of M.P. 234 C. by the addition of ethanolic hydrochloric acid and diethyl-ether. 4

The 9dimethylamino-methyl-anthracene used as starting material may be prepared as follows:

20 gramsof 9-chloromethyl-anthracene are heated with 10 grams of dimethylamine in cc. of ethanol for 5 hours in an autoclave at 100 C. The reaction mixture is then evaporated to dryness under reduced pressure, the residue dissolved in ether and the solution extracted with 2 N-sodium hydroxide solution. After drying and evaporation of the ethereal solution there is obtained 9-dimethylamino-methyl-anthracene which after crystallization from ethanol melts at 6566 C.

Example 9v 12 grams of B-[9zl0 dihydro 9:10-ethano-(1:2)-9- anthryl)-propionic acid dimethylamide in 50 cc. of tetrahydrofuran are added dropwise' withfstirrin g at room tem perat'ure to a suspension of 3.5 grams of lithium-aluminturn-hydride in 100 cc. of dry tetra-hydrofuran; the mixture is then boiled under reflux for 2 hours. 4 cc. of water and 10 cc. of sodium hydroxide solution of 15% strength are then added dropwise while cooling with ice, and the pr p ate whiclrset'tles out is filtered. The filtrate is which melts at 8890 C. after sublimation; its hydrochloride melts at 205-206 C.

The it-[9:10 dihydro 9:lO-ethano-(l:2)-9-anthryl]- propionic acid dimethylamide used as starting material may be prepared as follows:

A solution of 10 grams of ,8-(9-anthryl)-propionic acid [prepared as described by F. H. C. Stewart, Australian Journal of Chem. 13, 483 (1960)] in 200 cc. of dimethylformamide is saturated with ethylene and the mixture heated in an autoclave for 24 hours at 170 C. After cooling, 500 cc. of water are added the precipitate formed filtered off. The precipitate is recrystallized from ethanol to yield ,B-[9:10 dihydro-9:l0-ethano-(1:2)-9-anthryl]- propionic acid of the formula 6 0x a coorz in the form of crystals melting at 218219 C.

10 grams of the above acid are boiled with 500 cc. of thionyl chloride for 4 hours and the mixture evaporated to dryness under reduced pressure to yield a crystalline residue which is dissolved in 50 cc. of benzene. To this solution there is added dropwise at room temperature, with stirring, a solution of 5 grams of dimethylamine in 50 cc. of benzene. After 2 hours 100 cc. of water are added, the benzene layer separated, dried over sodium sulphate and evaporated. There remains crystalline fi-[9zl0-dihydro 9:10 ethano (1:2) 9 anthryll-propionic acid dimethylamide which can be used without further purification.

Example 10 A solution 14.0 grams of 2-chloro-anthracene-(9)-aldehyde in 200 cc. of dimethyl-formamide is saturated with ethylene and then heated in an autoclave for 24 hours at 170 C. The dimethylformarnide is then distilled off in vacuo. A viscous oil remains behind which is dissolved in 100 cc. of ethanol; after the addition of 10 grams of monomethylamine, the reaction mixture is heated in a bomb tube for 4 hours at 90 C. The solution is evaporated to dryness, the residue dissolved in 200 cc. of ethanol and, after the addition of 2 grams of Raney nickel, hydrogenated under 5 atmospheres gauge pressure. After filtering ofl? the catalyst, the reaction mixture is evaporated to dryness under reduced pressure. The residue is boiled with 100 cc. of 2 N-hydrochloric acid and the hydrochloric acid solution is separated off. On cooling, an oil separates which crystallizes after being allowed to stand for some time. There is obtained 2-chloro-9-methylaminomethyl 9:10-dihydro-9:10-ethano-(1:2)-anthracene-hydrochloride of the formula in the form of white crystals which melt at 223-226 C. after crystallization from water.

The 2-chloro-anthracene-(9)-aldehyde used as starting material may be prepared as follows:

A mixture of 42 grams of 2-chloro-anthracene, 54 grams of N-methyl-formamide, 60 grams of phosphorus oxychloride and 40 cc. of dichloro-benzene is heated for 2 hours at 95 C. with stirring. A solution of 280 grams of crystalline sodium acetate in 500 cc. of water is then added. A precipitate settles out which is filtered off and boiled with ethanol. The hot ethanol solution is filtered. On cooling the filtrate, 2-chloroanthracene-(9)-aldehyde separates in the form of yellow needles which melt at 148- 150" C. after recrystallization from glacial acetic acid.

Example 11 A solution of 5.0 grams of dimethylamine in 50 cc. of benzene is added dropwise and with stirring to 4.0 grams of 1:5-dichloro-9 10-dihydro-9: 10-ethano-(1:2)- anthracene-9-carboxylic acid chloride in 50 cc. of benzene at room temperature. After 2 hours, 100 cc. of water are added and the benzene layer is evaporated to dryness under reduced pressure. The residue is dissolved in 50 cc. of absolute tetrahydrofuran and the resulting solution. added dropwise and with stirring to a mixture of 2.0 grams of lithium aluminium hydride and 50 cc. of tetrahydrofuran. The mixture is heated to the boil for 2 hours and then decomposed by the addition of water and sodium hydroxide solution of 15% strength. After filtering off the precipitate Which has settled out and evaporating the filtrate, an oil remains which is dissolved in 10 cc. of ethanol. The solution is treated with 0.5 cc. of 10 N-ethanolic hydrochloric acid and the hydrochloride formed is precipitated by the addition of diethyl ether. There is obtained 1:5-dichloro-9-dimethylamino-methyl 9:10 dihydro-9:10-ethano-(1:2)-anthracene-hydrochloride of the formula in the form of crystals melting at 158162 C.

The 1:5 dichloro 9: 10 dihydro-9:10-ethano-(1:2)- anthracene-9-carboxylic acid chloride used as starting material may be prepared as follows:

A solution of 12 grams of 1:5-dichloro-anthracene-(9)- carboxylic acid in 200 cc. of dimethyl-formamide is saturated with ethylene and then heated for 24 hours at C. in an autoclave. The residue which remains after the solution has been evaporated under reduced pressure is dissolved in 2 N-sodium hydroxide solution and filtered through carbon. On acidification of the solution crude 1:5-dichloro-9:10-dihydro-9z10-ethano (1:2) anthracene-9-carboxylic acid precipitates which is filtered off and dried. 10 grams of this acid are boiled for 2 hours with 200 cc. of thionyl chloride. When the solution has been evaporated there remains an oil which crystallizes slowly. After recrystallization from petroleum ether there is obtained 1:5-dichloro-9z10-dihydro 9: 10 ethanomelting at 132135 C.

Example 12 12. g. of B-[9:10-dihydro-9:10-ethano-(1:2)-anthryl]- propionyl chloride in 75 ml. of methylenechloride are stirred dropwise into a solution of 7 g. of ,B-hydroxyethylpiperazine in 75 ml. of methylenechloride. The whole is stirred for 3 hours at room temperature, and the precipitate formed is then filtered off. The filtrate is evaporated and the residue dissolved in 2 N-hydrochloric acid and extracted with ether. The acidic extract is alkalinized and extracted with methylenechloride. The methylenechloride is separated, dried over sodium sulfate and evaporated. The residue, (B-[9z10-dihydro-9: l-ethano-(1:2)- anthryl] -propionic acid-N'- (fl-hydroxyethyl) -piperazide is dissolved in 100 ml. of absolute tetrahydrofuran. This solution is added dropwise to a suspension of 7.5 g. of lithium aluminum hydride in 100 ml. of tetrahydrofuran, and the whole is heated for 2 hours at 50 C., then cooled, whereupon 8 ml. of water, 8 m1. of 15% sodium hydroxide solution and 24-ml. of water are successively dropped in. The resulting precipitate is filtered oil and the filtrate is evaporated under vacuum, to leave an oily residue, namely (9-[-y-(N-hydroxyethy1 piperazino)-propyl]- 9:10-dihydro-9:IO-ethano-(l:2)-anthracene), which is dissolved in 100 ml. of ethanol. On addition of 10 ml. of 10% alcoholic hydrochloric acid a precipitate is obtained which is recrystallized from methanol, to yield 9-['y-(N' hydroxyethyl piperazino)-propyl]-9:10-dihydro-9:10-ethano-(1:2)-anthracene dihydrochloride of the formula in white crystals melting at 266 to 268 C.

Thi product may be incorporated, for example, in tablets of the following composition:

Example 13 34 g. of fi-[9,10-dihydro-9,10-ethano-(1,2)-9-anthryl1- propionic acid monomethylamide in 150 ml. of absolute tetrahydrofuran are stirred dropwise at room temperature into a suspension of 10 g. of lithium-aluminium hydride in 250 ml. of absolute tetrahydrofuran, and the mixture is heated for 3 hours at 60 C. and then cooled to 10 C. 10 ml. of water and 10 ml. of 15% sodium hydroxide solution are then dropped in and the precipitate formed is filtered off. The filtrate is evaporated under vacuum, to leave an oil which is dissolved in 50 ml. of ethanol. On addition of 10 N-ethanolic hydrochloric acid and ether, the 9-( -methy1aminopropyl)-9,10-dihy- 12 dro-9,10-ethano-(1,2)-anthracene hydrochloride of the formula CH2CH2CH2NH-CH3 H01.

precipitates in the form of White crystals which melt at 230 to 232 C. after recrystallization from isopropanol.

The fi-[9,10-dihydr0-9,10-ethano-( 1,2) -9-anthryl] -propionic acid monomethylamide used as starting material can be prepared in the following manner:

While cooling a solution of 50.0 g. of B-[9,l0-dihydr0- 9,10-ethano-(1,2)-9-anthryl]-propionylchloride in /2 liter of methylenechloride about 20 g. of monomethylamine is introduced into it in the course of one hour. 200 ml. of water are then added, the methylenechloride layer is separated, dried over sodium sulphate and the solvent is distilled oflf, to yield ii-[9,10-dihydro-9,10-ethano-(1,2)-9- anthrylJ-propionic acid monomethylamide which melts at 158 to 161 C. after recrystallization from a mixture of methylenechloride-l-petroleum ether.

Tablets, each containing 25 mg. of active principle, can be prepared, for example, from the following ingredients: Mg. 9 ('y methylamino-propyl) 9,10 dihydro-9,10-

ethano-(1,2)-anthracene-hydrochloride 25 Lactose 35 Wheat starch 44.4 Colloidal silicic acid 6 Magnesium stearate 0.6 Talc 9 Example 14 A solution of 6.8 g. of B-[10-chloro-9,10-dihydro-9,10- ethane-(1,2)-9-ant hryl]-propionic acid dimethylamide in 40 ml. of absolute tetrahydrofuran is stirred dropwise into a suspension of 2.5 g. of lithium-aluminium hydride in 60 ml. of absolute tetrahydrofuran. The mixture is then heated for 3 hours at 70 C., cooled to room temperature and 12 ml. of water are cautiously added. The precipitate formed is filtered off, and the filtrate evaporated under vacuum, the oily residue dissolved in ether and the ethereal solution is extracted with 2 N-hydrochloric acid. The acid solution is alkalinized with 10 N-sodium hydroxide solution and the precipitated base is extracted with ether. The extract is dried and evaporated, to leave 9-y-dimethylaminopropyl 10 chloro 9,10 dihydro-9,l0-ethano- (1,2)-anthracene of the formula whose hydrochloride melts at 225-226 C.

The ;3-[ l0 chloro 9,10 dihydro-9,10-ethano-( 1,2) -9- anthryl]-propionic acid dimethylamide used as starting material can be prepared in the following manner:

30 grams of 10-chloro-9-anthraldehyde are stirred into a suspension of 8 g. of sodium borohydride in 200 ml. of ethanol. After 1.hour 150 ml. of water are added. A precipitate is formed which is filtered oif and recrystallized from dimethylformamide-f-methanol, to yield crystalline 9-hydroxymethyl-IO-ohloroanthracene melting at 203-205 c. v

26 grams of 9-hydroxymethyl-IO-chloroanthracane are mixed with 14 g. of thionylchloride in ml. of dioxau and refluxed for 2 hours. After cooling, 9-chloromethyl- 10-chloroanthracene precipitates in crystalline form. After recrystallization from hexane the compound melts at 168- 170 C.

16 grams of malonic acid diethyl ester are added to a suspension of 2.5 g. of sodium hydride in 300 ml. of benzene and the whole is heated for 2 hours at 80 C. 24 grams of 9-chloromethyl-10-chloroanthracene are added and the mixture is refluxed for 7 hours. 200 ml. of water are then added at room temperature and the benzene layer is separated. After evaporation of the solvent 1-(10-chloro-9-anthryl) 2,2 ethanedicarboxylic acid diethyl ester is obtained; after recrystallization from isopropanol it melts at 8893 C.

When 27 g. of this ester are boiled in a solution of 80 ml. of 2 N-sodium hydroxide solution and 100 ml. of alcohol and then acidified with 5 N-hydrochloric acid, there is obtained the 1-(10-chloro-9-anthryl)-ethane-2,2- dicarboxylic acid (melting at 216 C.) which on heating to 220 C. gives rise to ,8-(-chloro-9-anthryl)-propionic acid by decarboxylation; this compound melts at 190 194 C. after recrystallization from dioxan+petroleum ether.

A solution of 12 g. of fl-(10-chloro-9-anthryl)-propionic acid in 250 g. of toluene is heated in an autoclave with ethylene for 20 hours at 170 C. On cooling, crystalline ;3-[10-chloro-9,10-dihydro 9,10 ethano-(1,2)-9- anthryl1-propionic acid melting at 280 C. is obtained.

8 grams of this acid are heated for 2 hours with 80 ml. of thionylchloride. On evaporation of the excess thionylchloride, B-[10-chloro-9,10-dihydro-9,10-ethano-(1,2)-9- anthryl]-propionic acid chloride is obtained which melts at 145-150 C. after recrystallization from hexane.

Dimethylamine is injected for one hour into a solution of 7.5 g. of the acid chloride in 75 ml. of benzene. The precipitate formed is filtered off and the filtrate evaporated under vacuum, to leave a residue which is recrystallized from ether, to yield ,8-[10-chloro-9,10-dihydro- 9,10-ethano-(1,2) 9 anthrylJ-propionic acid dimethylamide in crystals melting at 143-147 C.

Example 17 grams of fi-[Z-chloro 9,10 dihydro 9,10 ethano- (1,2)-9-anthryl] -propionic acid dimethylamide in 100 ml. of absolute tetrahydrofuran are stirred dropwise into a suspension of 5 g. of lithium-aluminium hydride in 100 ml. of absolute tetrahydrofuran, and the mixture is stirred for 5 hours at 60 C., then cooled and ml. of water are added. The precipitate formed is filtered off and the filtrate evaporated under vacuum, to leave an oil which is mixed with 2 ml. of 10 N-hydrochloric acid in alcohol and ether, to yield 2-chloro-9-'y-dimethylaminopropyl- 9,10-dihydro-9,10-ethano-(1,2)-anthracene hydrochloride of the formula which melts at 171173 C.,after recrystallization from 'isopropanol.

The fi-[2-chloro-9,10-dihydro-9,10 ethano 1,2) 9- anthryH-propionie acid dimethylamide used as starting material is obtained by the methods described in Example 14 from 2-chloroanthra-cene-(9)-aldehyde via.

(a) 2-chloro 9 hydroxymethylanthracene (M.P. 140- (b) 2 chloro 9 chloromethylanthracene (M.P. 140- (c) 1-(2-chloro-9-anthryl) 2 thane dicarboxylic acid diethyl ester (oil).

(d) 1-(2-chloro-9-anthryl) 2 ethane dicarboxylic acid 14 (e) B-[2-chloro-9,10-dihydro 9,10 ethano (1,2) 9- anthryl]-propionic acid (M.P. C.) (f) [i-[2-chloro 9,10 dihydro 9,10 ethano (1,2)-

9-anthryl]-propionic acid chloride (oil), (g) B-[2-chl0ro-9,l0-dihydro 9,10 ethano (1,2) 9- anthryl]-propionic acid dimethylamide (oil).

Example 16 A solution of 30 g. of fi-[3-chloro-9,10-dihydro-9,10- ethano-(1,2)-9-anthryl]-propionic acid dimethylamide in 200 ml. of absolute tetrahydrofuran is stirred dropwise under nitrogen into a suspension of 6 g. of lithium-aluminium hydride in 200 ml. of absolute tetrahydrofuran. The reaction mixture is refluxed for 2 hours, cooled, and 6 ml. of water, 6 ml. of sodium hydroxide solution of 15% strength and 18 ml. of water are added. The whole is completely evaporated and the residue dissolved in 200 m1. of 2 N-hydrochloric acid, the solution extracted with ether and the residual aqueous phase is rendered clearly alkaline with concentrated sodium hydroxide solution While being cooled, and extracted with ether. The ethereal extracts are dried over sodium sulphate and evaporated to form an oily residue which is once more dissolved in ether and mixed with the calculated amount of maleic acid in ether, to yield a crystalline maleate of the formula CH CH CH CHN 3 HCCOOH ll HCCOOH A solution of 25 g. of 18-[3-chloro-9,10-dihydro-9,10- ethano-(1,2)-9-anthryl] -propionic acid monomethylamide in 200 m1. of absolute tetrahydrofuran is stirred dropwise under nitrogen into a suspension of 6 g. of lithiumaluminium hydride in 200 ml. of absolute tetrahydrofuran. The reaction mixture is refluxed for 2 hours, cooled, and 6 ml. of water, 6 ml. of sodium hydroxide solution of 15 strength and 18 ml. of water are added. The batch is completely evaporated under vacuum, the residue dissolved in 500 ml. of 2 N-hydrochloric acid, the solution extracted with ether and the aqueous residue rendered distinctly alkaline with concentrated sodium hydroxide solution while being cooled, and then extracted with ether. The ethereal extracts are dried over sodium sulphate and evaporated, to yield 3-chloro-9-( monomethylaminopropyl) 9,10 dihydro 9,10 ethano 1,2 anthracene of the formula NliCH CH CH CH 1 5 Example 18 CH2N(CH3)2 whose hydrochloride melts at 244245 C.

Example 19 7 grams of N-acetyl-Z-chloro 9 ethylaminomethyl 9,10-dihydro-9,l-ethano-(l,2)-anthracene in 50 m1. of absolute tetrahydrofuran are dropped into a suspension of 2 g. of lithium-aluminium hydride in 50 ml. of absolute tetrahydrofuran and the whole is stirred for 4 hours at 50 C., then cooled to room temperature, and 15 ml. of water are cautiously added. The precipitate formed is filtered off and the filtrate evaporated under vacuum to dryness, to leave an oil which is dissolved in 10 ml. of ethanol. On addition of 1.5 ml. of 10 N-hydrochloric acid in alcohol and ether, the hydrochloride of 2-chloro-9-diethylarninoethyl-9,10-dihydro-9,10-ethano-(1,2) anthracene of the formula settles out in white crystals melting at 231 C.

The N-acetyl-2-chloro-9-ethylaminomethyl 9,10 dihydro-9,10-ethano-(1,2)-anthracene used as starting material may be obtained by reacting 2-chloro-9-ethylaminomethyl-9,10-dihydro-9,lO-ethano-( 1,2) anthracene [prepared with ethylamine, as described in Example 10] with acetic anhydride at 110120 C. for hours.

Example 20 A mixture of 36 g. of -ch1oro-9,10-dihydro-9,10- ethano-(1,2) -9-anthracene aldehyde and a saturated ethanolic solution of ethylamine is heated in an autoclave for 5 hours at 80 C., whereupon the solution is evaporated under vacuum.

The residue is dissolved in 250 ml. of ethanol, 5 g. of Raney nickel are added, and the mixture is hydrogenated at room temperature. After the catalyst has been filtered off and the solvent evaporated, there remains 9-ethylaminornethyl-lO-chloro 9,10 dihydro 9,10 ethanoanthracene of the formula which melts at 88-91 C. after recrystallization from hexane. The hydrochloride melts above 300 C.

Example 21 A solution of 14 g. of N-acetyl-9-ethylaminomethyl-10- chl'oro-9, l0-dihydro-9, l O-ethano- 1,2) -anthracene in 50 ml. of absolute tetrahydrofuran is dropped into 5 g. of lithium-aluminium hydride in ml. of absolute tetrahydrofuran, and the batch is then heated for 4 hours at 60 C., whereupon 20 ml. of Water are cautiously added at room temperature. The precipitate formed is filtered 01f and the filtrate evaporated to dryness under vacuum, to yield 9-diethylaminomethyl-lO-chloro 9,10 dihydro- 9,10ethano-( l,2)-anthracene of the formula which melts at 116-118 C. after recrystallization from ethanol. Its hydrochloride melts at 200-205 C.

The N-acetyl-9-ethylaminomethyl-lO-chloro 9,10 dihydro-9,10-ethano-(1,2)-anthracene used as starting material may be prepared by reacting 9-ethylaminomethyl- 10-chloro-9, l 0-dihydro-9', IO-ethano- 1,2 -anthracene (of. Example 18) with acetic anhydride at C. The compound melts at 203-205" C.

Example 22 13 grams of 9-dimethylaminomethyl-9,10 dihydro-9,l0 ethano-(l,2)-anthracene are stirred into a mixture of 100 ml. of concentrated sulphuric acid and 10 ml. of concentrated nitric acid, and the mixture is heated for 1 hour at 60 C., then poured over ice and rendered alkaline with 10 N-sodium hydroxide solution. On extraction with methylenechloride, drying and evaporation, a solid residue is obtained which is recrystallized from alcohol, to yield 1,3,6-trinitro-9-dimethylaminornethyl-9,IO-dihydro 9,10- ethano-(1,2)-anthracene of the formula in yellow crystals melting at 183-184" C.

We claim: 1. A compound having the formula phenylene and amino-1,2-phenylene, and Ph stands for a member selected from the group consisting of phenyl, lower ralkoxy-phen'yl, lower alkyl phenyl, halogenophenyl, tr-ifluorornethyl-phenyl, and amino-phenyl, and the 17 18 lower alkyl and alkenyl portion in said substituents con- 3. A compound as claimed in claim 2, wherein alk tain at most 7 carbon atoms and the cycloalkyl portions is methylene or propylene-(1:3). in said substituents contain from 4 to 7 ring carbon atoms, 4. A compound as claimed in claim 1, said compound and R is a member selected from the group consisting being the 9-(N-acetyl-methylaminomethyl)-9:IO-dihydroof lower alkanoyl and Ph-lower alkanoyl wherein lower 9: 10-ethano-(1:2)-anthracene. alkanoyl contains at most 3 carbon atoms, and Ph" stands 5. A compound as claimed in claim 1, said compound for a member selected from the group consisting of being 2-chloro 9 (N-acetyl-ethylaminomethyl)-9:10- phenyl, lower alkoxy-phenyl, lower alkyl-phenyl, halodihydro-9:IOethano-(l:2)-anthracene.

geno-phenyl, trifiuoromethyl-phenyl, and amino-phenyl. 6. A compound as claimed in claim '1, said compound 2. A compound as claimed in claim 1, said compound 10 being 9-(N-acetyl-ethylaminomethyl) 10 chl0ro-9210- having the formula dihydro-9: 10-ethano-( 1 :2)-anthraoene.

R N 0 references cited. alk-N: 1

R2 15 HENRY R. JILES, Primary Examiner HARRY I. MOATZ, Assistant Examiner Ph Ph US. Cl. X.R.

260-558, 559, 293, 326.8, 247, 243, 268, 57018, 544, 469; wherem alk IS a lower alkylene radical, R 1s hydrogen 2O 424 320 or lower alkyl, R is lower alkanoyl and Ph and Ph are unsubstituted or halogeno-su-bstituted 1:2-phenylene radigals.

CASE +68'T/l+2/53 81/ UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. %,l+89,7qq Date January 13, 1970 Inv n PAUL SCHMIDT ET AL It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Column 1, line 46, after"(l:2)", insert Column 2, line 7, "cyclopentyl" should be cyclopentenyl Column 2, line 22, "(1:6), 1:5" should read Column 2, line 36, change "of" to read or Column 8, line 2, "ethano" should be ethanol Column 8, line 68, delete the and insert Column 15, line 1, after "2-chloro-" insert 9- iii-Emil) PM) SEALED was) 1971 SEA-L) Am naval- MOM mama. W, JR.

Commissioner of Patents I 

